In North America almost everyone flies mode 2, but a lot of the rest of the world flies mode 1. The supposed advantage of mode 2 is that the right stick is similar to the stick in a real aircraft. The supposed advantage of mode 1 is more precision because you are using both hands for your primary controls. To be quite honest I don't think that it makes all that much difference. Personally, I use Mode 1.
I would recommend setting up your radio for the same mode as most of the people in your area.............