To answer your questions:

1) No. Each copy of AFP/D or XTR comes with a usb dongle that contains copy-protection codes. You will need to plug it into the PC that you want to play on

2) Yes. Some Tx that has DSC function may be automatically switched on depending on the adapter design

3) Yes, you can use all the programmable mixes in your Tx but you have to assign the proper channel and calibrate the software

Hope this helps