E-Flite blade transmitter does have a trainer connector on the back. The problem with using it to control a flight simulator is that the PPM signal is already CCPM-ixed and this mix can't be turned of. As none of the existing simulators can work with the mixed signal (because a single channel input results in multiple servo movements), Horizon claims that E-flite Blade CP transmitter (same thing as ESky "Channels Six" CCPM transmitter) can't be used with simulators...
The best simulator, which can use a 3rd-paty interface, is AeroFly Pro Deluxe. Please be aware that AFPD still needs its original interface for copy protection, i.e. one can't just copy the CD to sell the sim and use the copy with another interface!
I hope you find this information helpful.

Boris