I agree with 2slow, you can do it... but why would you want too?
The purpose of an airliner is to take off, go a long way and land.
It is not designed to do any aerobatics - so once you have mastered the building and test flown it... what do you do with it?? Fly in circles...
That said, there have been a number of people that have made giant AC, B52, 747 and the A380 come to mind. If it makes you happy and you can afford it - carry on! [8D]
Just be sure to make it in pieces that can fit in your means of transport!
