yes, it is explained in detail in the instructions that came with the ESC
( this is from the instruction sheet that comes with the GreatPlanes ElectriFly Silver Series 25Amp ESC )
"Remove the red wire from the ESC's receiver plug. To do this use a small flat screwdriver to carefully raise the plastic tab holding the metal pin, Carefully pull the red wire out of the receiver plug and insulate the pin with heat-shrink tubing or electrical tape."