to eliminate the tx/rx, try plugging a servo into the throttle channel and see if you get what you expect. if the servo moves correctly with throttle input, the problem lies in your esc or motor.

is aligns brushless setup "sensorless"? if so, your motor could be in a "dead spot" which would result in funny noises and prevent it from starting. if that were the case simply rotating the motor a bit would get it going.