RE: nx76 + mt2=??
The OS .18 has allot more power than the stock NT .16 regardless of what it says on paper and is a direct replacement. Stock parts will last longer with the OS engine and economy will be better than any big block that you could put in it with the exception of a 4 stroke.
With the power output of the .46 engine you will break allot of parts and you run times will be less than 5 minutes with the stock tank. There is only a limited number of places that you can add a larger tank and then you will only see a marginal improvement in run time.
If you still decide to use the .46 I would recommend,
Alloy brake seat,
Steel pinion gears,
Machined and hardened diff gears with the machined cross shaft,
Some form of axle swap either the Swift mod or the Maxx mod,
The stock chassis flexes a considerable amount with the stock motor so you will need to find a JT chassis or Dr Honda's when he finds the time to make them. You might even be able to use a Magnum chassis with the top plate but then you will need a new center dog bone and the Magnums brake seat.
This is all I can think of right now and I am sure that I am forgetting something. But you are basically going to be spending real close to what a good used Genesis sells for and the truck would almost if not completely be uncontrollable.
rolland