once you've got 6-7 tanks through it start leaning the HSN. 1/8th turn at a time. You don't need to do it per tank, just run it in an open space full throttle and see what it goes like. If it splutters and doesnt accelerate cleanly then turn it another 1/8th. At its best tune it sould scream like a banshee and be leaving a faint trail of white smoke. As you sound quite new to the hobby I reccomend at this point richening it a little to be on the safe side. In time you will get used to the sounds a well tuned engine makes and it will all become easier. When the HSN needle is tuned you then want to tune the LSN. Do this in 1/12th turns and to check it squeeze the fuel line and the engine should idle for about 5 seconds before dying and the revs will pick up slightly before it cuts out.
Thats your engine tuned now thrash the pants off it