My P-51 PTS came that way, and I fly my ModelTech Extra 300S with an inverted engine at 45 degrees.

( You didn't specify upright 45 degrees or inverted 45 degrees... )

I haven't had a problem with either. Nothing different in terms of weight too.

Upright you would still have a bit of weight on one side due to the muffler, etc. which is easy to offset by moving the battery pack to the other side.... no biggie.