AFPD should run in Windows/Vista in Intel Mac under BootCamp or Parallels, but you will need to choose a computer model that comes with one of the recommended 3D-graphics cards. It is mandatory that your computer meets the minimum system requirements. The Intel GMA graphics card that comes with lower end Mac models is not compatible. AFPD uses OpenGL, which Parallels 3.0 has better support for. The release notes for Parallels 3.0 list AFPD as one of the apps known to work. Using BootCamp requires you to log out of OSX and reboot into Windows whenever you want to use your sim, which is inconvenient. Using something like Parallels would allow you to run your sim without having to log out of OSX, provided you have sufficient RAM in your computer to run both OS's side by side. I would recommend having at least 1.5 GB in your computer for this to work well.