Top RPM can be 500 to 800 different without affecting flight performance.

If one engine is slow spooling up on a tail dragger you are likely to be all over the runway before the airplane is in the air. Big engines on a tail dragger could be a handful.

If one engine is slow spooling up with tricycle gear the airplane will flat turn as the front wheel lifts off. One of my tricycle gear twins almost always headed straight for the big shade tree at lift off. The airplane and the tree had an agreement about a clean mess flight path but rarely consulted me.

My limited experience with Twinsync suggests it would be a good solution.

Bill