I'm a lefty as well. I fly Mode 2, I think.

My TX is set up just like all the righties fly. Left stick=throttle and rudder. Right stick=elevator and ailerons.

I've never had a problem with it. Actually, I'll bet money that I would crash in 2 seconds if I switched.

It's a right-handed world. We lefties are constantly adapting to it. Just set it up normal and fly it. You won't ever know the difference.