In the air, there is no difference.

Landing, there is little difference, except that tail draggers will break more props, the nose wheel helps keep the prop away from the ground.

But taking off, trike geared planes are generally much easier to set up and make work correctly. So in that key area, the tail dragger is at a disadvantage. It is possible to make a tail dragger just about as easy to handle on teh ground as a typical trike, and there are trikes that handle badly on the ground. But in general, trikes are easier to learn with when it comes to takeoffs and landings.